Stability Analysis and Stabilization of Fuzzy State Space Models

Die Dissertation von <A HREF=" http://www.shaker.de/Online-Gesamtkatalog/Details.asp ?ISBN=3-8322-5552-4 ">Kunping Zhu Stability Analysis and Stabilization of Fuzzy State Space Models (ISBN-10: 3-8322-5552-4, ISBN-13: 978-3-8322-5552-7)wurde parallel im Shaker Verlag veröffentlicht Abstract: Fuzzy control has achieved numerous successful industrial applications. However, stability analysis for fuzzy control systems remains a difficult problem, and most of the critical comments on fuzzy control are due to the lack of a general method for its stability analysis. Although significant research efforts have been made in the literature, appropriate tools for this issue have yet to be found. This thesis focuses on the problem of stability of fuzzy control systems. Both linguistic fuzzy models and T-S fuzzy models are discussed. The main work of this thesis can be summarized as follows: (1). A necessary and sufficient condition for the global stability of linguistic fuzzy models is given by means of congruence of fuzzy relational matrices. (2). A hyperellipsoid-based approach is proposed for stability analysis and control synthesis of a class of T-S (affine) fuzzy models with support-bounded fuzzy sets in the rule base. (3). Approaches of BMI-based fuzzy controller designs are proposed for the stabilization of T-S fuzzy models. (4). For the general T-S type fuzzy systems with norm-bounded uncertainties and time-varying delays, sufficient robust stabilization conditions are presented by employing the PDC-based fuzzy state feedback controllers. On stability analysis of T-S fuzzy models, most reported results based on the method of common quadratic Lyapunov functions require that each subsystem of the fuzzy models be stable in order to guarantee the stability of the overall systems. This restriction is overcome in our results by means of employing the structural information in the fuzzy rules

The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability

人类与其他动物相比的重要区别在于人类拥有高等认知能力，这种能力集中体现在学习记忆和语言表达方面。厦门大学医学院神经科学研究所王鑫教授团队发现人科动物特异性基因USP6作为一个新的NMDA受体调控因子，可通过去泛素化途径调节NMDA型谷氨酸受体的降解和稳定性，进而调控突触可塑性和学习记忆能力。 本研究工作由王鑫教授指导完成，博士生曾凡伟、马学海与硕士生朱琳为共同第一作者，王鑫教授为通讯作者。Ubiquitin-specific protease (USP) 6 is a hominoid deubiquitinating enzyme previously implicated in intellectual disability and autism spectrum disorder. Although these findings link USP6 to higher brain function, potential roles for USP6 in cognition have not been investigated. Here, we report that USP6 is highly expressed in induced human neurons and that neuron-specific expression of USP6 enhances learning and memory in a transgenic mouse model. Similarly, USP6 expression regulates N-methyl-D-aspartate-type glutamate receptor (NMDAR)-dependent long-term potentiation and long-term depression in USP6 transgenic mouse hippocampi. Proteomic characterization of transgenic USP6 mouse cortex reveals attenuated NMDAR ubiquitination, with concomitant elevation in NMDAR expression, stability, and cell surface distribution with USP6 overexpression. USP6 positively modulates GluN1 expression in transfected cells, and USP6 down-regulation impedes focal GluN1 distribution at postsynaptic densities and impairs synaptic function in neurons derived from human embryonic stem cells. Together, these results indicate that USP6 enhances NMDAR stability to promote synaptic function and cognition.This work was partially supported by the National Natural Science Foundation of China (31871077, 81822014, 81571176 to XW; 81701349 to Hongfeng Z.; 81701130 to QZ; and 81471160 to HS), the National Key R&D Program of China (2016YFC1305900 to XW and HS), the Natural Science Foundation of Fujian Province of China (2017J06021 to XW), the Fundamental Research Funds for the Chinese Central Universities (20720150061 to XW and 20720180040 to ZS), Open Research Fund of State Key Laboratory of Cellular Stress Biology, Xiamen University (SKLCSB2019KF012 to QZ), and China Postdoctoral Science Foundation (2017M612130 to QZ).该研究得到了国家自然科学基金面上项目和优秀青年基金项目的支持

Fault Detection and Diagnosis for Nonlinear and Non-Gaussian Processes Based on Copula Subspace Division

A novel copula subspace division strategy is proposed for fault detection and diagnosis. High-dimensional industrial data are analyzed in two elemental subspaces: margin distribution subspace (MDS) modeled by joint margin distribution, and dependence structure subspace (DSS) modeled by copula. The highest density regions of two submodels are introduced and quantified using probability indices. To improve the robustness of the monitoring index, a hyperrectangular control boundary in MDS is designed, and the equivalent univariate control limits are estimated. Two associated contribution indices are also constructed for fault diagnosis. The interactive relationships among the root-cause variables are investigated via a proposed state chart. The effectiveness and superiority of the proposed approaches (double-subspace and multisubspace) are validated using a numerical example and the Tennessee Eastman chemical process. Better monitoring performance is achieved compared with some conventional approaches such as principal component analysis, independent component analysis, kernel principal component analysis and vine copula-based dependence description. The proposed multisubspace approach fully utilizes univariate-based alarm data with a dependence restriction modulus, which is promising for industrial application

Fault Detection and Diagnosis for Nonlinear and Non-Gaussian Processes Based on Copula Subspace Division

A novel copula subspace division strategy is proposed for fault detection and diagnosis. High-dimensional industrial data are analyzed in two elemental subspaces: margin distribution subspace (MDS) modeled by joint margin distribution, and dependence structure subspace (DSS) modeled by copula. The highest density regions of two submodels are introduced and quantified using probability indices. To improve the robustness of the monitoring index, a hyperrectangular control boundary in MDS is designed, and the equivalent univariate control limits are estimated. Two associated contribution indices are also constructed for fault diagnosis. The interactive relationships among the root-cause variables are investigated via a proposed state chart. The effectiveness and superiority of the proposed approaches (double-subspace and multisubspace) are validated using a numerical example and the Tennessee Eastman chemical process. Better monitoring performance is achieved compared with some conventional approaches such as principal component analysis, independent component analysis, kernel principal component analysis and vine copula-based dependence description. The proposed multisubspace approach fully utilizes univariate-based alarm data with a dependence restriction modulus, which is promising for industrial application

Purification Process and In Vitro and In Vivo Bioactivity Evaluation of Pectolinarin and Linarin from <i>Cirsium japonicum</i>

Pectolinarin and linarin are two major flavone O-glycosides of Cirsium japonicum, which has been used for thousands of years in traditional Chinese medicine. Pharmacological research on pectolinarin and linarin is meaningful and necessary. Here, a process for the purification of pectolinarin and linarin from C. japonicum was established using macroporous resin enrichment followed by prep-HPLC separation. The results show the purity of pectolinarin and linarin reached 97.39% and 96.65%, respectively. The in vitro bioactivities result shows the ORAC values of pectolinarin and linarin are 4543 and 1441 µmol TE/g, respectively, meanwhile their inhibition rate of BSA-MGO-derived AGEs is 63.58% and 19.31% at 2 mg/mL, which is 56.03% and 30.73% in the BSA-fructose system, respectively. The COX-2 inhibition rate at 50 µg/mL of linarin and pectolinarin reached 55.35% and 40.40%, respectively. Furthermore, the in vivo bioassay combining of histopathologic evaluation and biochemical analysis of liver glutamic oxaloacetic transaminase, serum creatinine and TNF-α show pectolinarin can alleviate lipopolysaccharide (LPS)-induced acute liver and kidney injury in mice. Metabolomics analysis shows that pectolinarin attenuates LPS-challenged liver and kidney stress through regulating the arachidonic acid metabolism and glutathione synthesis pathways. Collectively, our work presents a solid process for pectolinarin and linarin purification and has discovered a promising natural therapeutic agent—pectolinarin

Pharmacodynamic Study of Polymerized Porcine Hemoglobin (pPolyHb) in a Rat Model of Exchange Transfusion

The objective of the present study is to evaluate the pharmacodynamic properties of polymerized porcine hemoglobin (pPolyHb) in an exchange transfusion model. Each of two groups of rats received a volume of pPolyHb or hetastarch that equalled 120–140% of estimated total blood volume (70 ml/kg) exchange transfusion. The results showed pPolyHb retained hemodynamic stability and exhibited superior volume expansion capability. Furthermore, pPolyHb effectively reverse anaerobic metabolism caused by a large amount of volume exchange. In comparison with hetastarch, pPolyHb increased blood oxygen content and tissue oxygenation. All these properties contribute to a higher effectiveness in sustaining the lives of rats in pPolyHb group

Hemin with Peroxidase Activity Can Inhibit the Oxidative Damage Induced by Ultraviolet A

Excessive reactive oxygen species (ROS), a highly reactive substance that contains oxygen, induced by ultraviolet A (UVA) cause oxidative damage to skin. We confirmed that hemin can catalyze the reaction of tyrosine (Tyr) and hydrogen peroxide (H2O2). Catalysis was found to effectively reduce or eliminate oxidative damage to cells induced by H2O2 or UVA. The scavenging effects of hemin for other free-radical ROS were also evaluated through pyrogallol autoxidation, 1,1-diphenyl-2-picrylhydrazyl radical (DPPH·)-scavenging assays, and phenanthroline–Fe2+ assays. The results show that a mixture of hemin and tyrosine exhibits strong scavenging activities for H2O2, superoxide anion (O2−·), DPPH·, and the hydroxyl radical (·OH). Furthermore, the inhibition of oxidative damage to human skin keratinocyte (HaCaT) cells induced by H2O2 or UVA was evaluated. The results show that catalysis can significantly reduce the ratio of cell apoptosis and death and inhibit the release of lactate dehydrogenase (LDH), as well as accumulation of malondialdehyde (MDA). Furthermore, the resistance to apoptosis was found to be enhanced. These results show that the mixture of hemin and tyrosine has a significantly protective effect against oxidative damage to HaCaT cells caused by UVA, suggesting it as a protective agent for combating UVA damage

Immune Safety Evaluation of Polymerized Porcine Hemoglobin (pPolyHb) - a Potential Red Blood Cell Substitutes.

Polymerized Porcine Hemoglobin (pPolyHb), a hemoglobin-based oxygen carrier (HBOC), was developed as a potentialred blood substitute for clinical applications. Assessment of its effects on the immune system is an important component of the overallsafety evaluation of HBOC. For this purpose, we assessed three infl ammation indicators, including complement C3a, IL-6, and TNF- αin cultured cells and in a rat model when pPolyHb was incubated or administrated with the cells/animals. Our results suggested that thelevels of these three indicators were not statistically changed upon pPolyHb stimulation, indicating that pPolyHb is not immunotoxicto cells and animals in this aspect